Dr. Roozbeh Abedini-Nassab

Mechanical Engineering

Biomechanics, Associate Professor

Biomedical Engineering

Postdoctoral Associate, Cornell University

Mechanical Engineering

Ph.D., Duke University

Electronics Engineering

University of Michigan - Shanghai Jiao Tong University










Students



Mohammad Mehdi Farzaneh

Mohammad Mehdi is a Masters student in Biomechanics. He works on developing magnetophroetic circuits.

Parisasadat Mohammadi

Parisasadat is a Masters student in Biomechanics. She is interested on developing magnetophroetic circuits.

Seyed Ahmad Seyedmorad

Seyed Ahmad is a Masters student in Biomechanics. He works on 3D-printed bones.

Seyed Abolfazl Momeni

Seyed Abolfazl is a Masters student in Biomechanics. He works on developing 3D magnetic fields useful in bioparticle manipulations.

Seyed Mohammad Mehdi Farzaneh

Seyed Mohammad Mehdi is a Ph.D. student in Energy Conversion. He works on developing magnetomicrofluidic chips to assemble single-cell assays.

Alumni

Sina Ahmadiasl, Negar Sadeghi Delouei, Ali Emamgholizadeh, Rahim Dashti, Erfan Farzam, Milad Alishahitoosi, Mahmood Nazari, Fateme Pourrezakhadar, Amirali Hanifi, Narmin Zarrinabadi, Samaneh Ghavidel, Nazanin Pajoohideh, Zahra Zandi, Fatemeh Hassani, Sheida Varzeshi, Iman gholami, Hedieh Jahangirpoori, and Atabak Mohammadi Moazed.

Skills

Here, students learn to use multiple skills. We have access to some facilities in TMU labs and elsewhere.

Singel Cell Analysis System

Single-cell analysis systems are becoming essential tools for biological and medical research; however, most existing platforms are still incapable of automating the analysis of large number of single cells with the flexibility and scalability of modern computer circuits. We are trying to make breakthroughs in this field by developing logic-based transport systems to control single cells in microfluidic environments.

Dynamics

We are interested in dynamics of small particles. We use this knowledge in theoretical calculation and simulation of particles trajectory in magnetophoretic circuits.

Fluid mechanics

We are interested in movement of small particles, such as biological cells in fluids. We use this knowledge in theoretical calculation and simulation of particles trajectory in magnetophoretic circuits.

Megnetophoretic circuits

As one of the inventors of the magnetophoretic circuits, we continue to work in this field and design novel circuits to precisely transport tiny particles and single cells.


Analogue and digital circuits

We use the electronic circuits and their concepts in our interdisciplinary research field. Combining the skills in mechanical and electrical engineering helps us in working on novel applications.


Computer Hardware

We have designed many computer related circuits, such as Power supply tester/loader, Automated BGA machine, Computer IR remote controller, Computer I/O board, and Internet based device remote controller.


Coding / Simulations / AI

We use different programming languages and software, including C++, Python, Visual Basic, Matlab, LabView, Ansys Maxwell, and Comsol, for our computational needs. We are interested in energy, force, and fluid simulations. We use the simulation results in designing our microchips. We are also interested in big data analysis, artificial intelligence (AI), and machine learning. We use these skills in analyzing the biosignals including genomic data from single cells.

Photo-lithography

Photolithography in the first step in most of our chip fabrication protocols. It is mostly used to pattern the thin films.


E-beam / Metal Evaporating

The metal evaporation is used in chip fabrication for making the required metallic layers.


Sputtering

Sputtering is sometimes used to creat the films in our chip fabrication.


Plasma Enhanced Chemical Vapor Deposition

We use PECVD in chip fabrication. We mostly use it for coating our chips with insulators.


Reactive Ion etching (RIE)

RIE is used to etch the channels in our chips.


Wire bonding

Wire bonding is used to electrically connect the chips to the outside world.


Microfluidic channel fabrication (soft lithography)

We use various techniques for fabricating microfluidic channels, based on PDMS.


3D Printing

We use 3D Printers to fabricate many things, such as microfluidic chips, fluid container chambers, and so on.



Publications

Selected Journal Publications (see full publication list at google scholar):

B. Lim, et al., “Magnetophoretic circuits for digital control of single particles and cells”, Nature Communications, 2014, 5, 3846.
L. Li, et al., “Monolithically integrated Helmholtz coils by 3- dimensional printing”, Applied Physics Letters, 2014, 104(25), 253505.
R. Abedini-Nassab, et al., “Characterizing the switching thresholds of magnetophoretic transistors”, Advanced Materials, 2015, 27(40), 6176-6180.
R. Abedini-Nassab, et al., “Magnetophoretic Conductors and Diodes in a 3D Magnetic Field”, Advanced Functional Materials, 2016, 26(22), 4026-4034.
R. Abedini-Nassab, et al., “Magnetophoretic Transistors in a 3-Dimensional Magnetic Field”, Lab on a Chip, 2016, 16, 4181-4188.
D. Y. Joh, et al., “Poly(oligo(ethylene glycol) methyl ether methacrylate) Brushes on High-κ Metal Oxide Dielectric Surfaces for Bioelectrical Environments”, ACS Applied Materials & Interfaces, 2017, 9(6), 5522-5529. (Co-first author)
R. Abedini-Nassab, “Nanotechnology and Nanopore Sequencing”, Recent Patents on Nanotechnology, 2017, 11(1), 34-41. (Editor’s Choice)
R. Abedini-Nassab, "Magnetomicrofluidic Platforms for Organizing Arrays of Single-Particles and Particle-Pairs", IEEE Journal of Microelectromechanical Systems, 2019, 28(4).
R. Abedini-Nassab and N. Mahdaviyan, “A Microfluidic Platform Equipped with Magnetic Nano Films for Organizing Bio-Particle Arrays and Long-Term Studies”, IEEE Sensors, 2020.
R. Abedini-Nassab and S. Bahrami, “Synchronous control of magnetic particles and magnetized cells in a tri-axial magnetic field”, Lab on a Chip, 21(10), 1998-2007.
M. Mantri, G. J Scuderi, R. Abedini-Nassab, M. FZ Wang, D. McKellar, H. Shi, B. Grodner, J. T. Butcher, I. De Vlaminck, “Spatiotemporal single-cell RNA sequencing of developing hearts reveals interplay between cellular differentiation and morphogenesis”, Nature Communications, 2021, 12(1), 1-13.
R. Abedini-Nassab, “Magnetometamaterials: Metamaterials with tunable magnetic matter conductivity”, Physical Review Applied, 2022, 17(1), 014020.
R. Abedini-Nassab, X. Ding, and H. Xie, “A novel magnetophoretic-based device for magnetometry and separation of single magnetic particles and magnetized cells”, Lab on a Chip, 2022, 22, 738-746.
R. Abedini-Nassab and R. Shourabi, “High-Throughput Precise Particle Transport at Single-Particle Resolution in a Three-Dimensional Magnetic Field for Highly Sensitive Bio-Detection”, Scientific Reports, 2022, 12(1), 1-15.
R. Abedini-Nassab, N. Sadeghidelouei, W. C. Shields IV, “Magnetophoretic Circuits: A Review of Device Designs and Implementation for Precise Single-Cell Manipulation", Analytica Chimica Acta, 2023.
R. Abedini-Nassab, E. Adibi, S. Ahmadiasl, “Characterization of AI-enhanced magnetophoretic transistors operating in a tri-axial magnetic field for on-chip bioparticle sorting”, Scientific Reports, 2024, 14(1), 2381.
R. Dashti and R. Abedini-Nassab, "A high-throughput hybrid electromicrofluidic platform for organizing single-cell protein secretion profiling assays", IEEE Sensors Journal, 2024, 24(6), 7448-7455.
R. Abedini-Nassab, MA. Toosi, Y. Shen, F. Maghsoodi, Y. Dan, "Magnetophoretic Capacitors Operating in a Tri-axial Magnetic Field for On-Chip Bio-Applications", IEEE Sensors Journal, 2025, 25(1).

Books
Roozbeh Abedini-Nassab, “Magnetomicrofluidic Circuits for Single-Bioparticle Transport”, Springer Nature, 2023.
Roozbeh Abedini-Nassab and Mehdi Movahedi, “Transport of Bioparticles in Microfluidic Chips”, Kharizmi, 2020 (In Persian).
Mehdi Movahedi and Roozbeh Abedini-Nassab, “Conductive and Magnetic Materials in Tissue Engineering”, Kharizmi, 2020 (In Persian).

Patent Applications
NONFOULING BIOSENSORS, US20200378916A1, 2020-12-03.
PLATFORMS FOR SINGLE CELL ANALYSIS, US20200269246A1, 2020-08-27.
MAGNETIC SINGLE CELL ARRAYS FOR PROBING CELL-DRUG AND CELL-CELL COMMUNICATION, US20180257075A1, 2018-09-13.

Conference Presentations
The 5th National Conference on New Technologies in Electrical, Computer and Mechanical Engineering of Iran, 2022.
The 3rd National Conference on Micro/Nanotechnology, Iran, 2022.
Biosensors and Bioelectronics, Phoenix, USA, 2016.
ASME ICNMM, Washington, DC, USA, Accepted.
RTNN Research Symposium 2016, Raleigh, USA, 2016.
Duke GradX, Durham, USA, 2016.
MEMS retreat, Duke University, Durham, USA, 2015. (Winner of three awards)
SMMO, Warsaw, Poland, 2007.
VCNSC, Arkansas, USA, 2007.
10th Computer and Electrical student conference, Isfahan, Iran, 2007.